Dear Subscriber,
Some concerning news has come out about the use of what has been presumed “safe” – CBD.
CBD (cannabidiol, a component of the marijuana and hemp plants) use has grown exponentially. I am not against it, but I have had concerns, and now great concerns. Why?
We know that there are tons of CBD receptors in the brain and nervous system. That is why the molecule is so valuable. The receptors are there for a reason. But just as opioid receptors are present for a reason, necessary for life, one can overdo a good thing, particularly in the very young.
New evidence suggests that CBD exposure in young mammals can alter the developing nervous system. We know that CBD crosses the placenta and can reach the brain of mammal embryos. It also is in mother’s milk. Now researchers are finding behavioral changes in animals so exposed during development.
Profound changes in parts of the brain of animals was observed, particularly the insular cortex. The animals, particularly female, showed altered behavior related to contact with other animals.
I am pasting the report from the NewAtlas below. While CBD might be perfectly safe for adults, if exposure to CBD can induce change behavior in animals exposed during pregnancy or lactation, then there are serious issues in the making of public perceptions that CBD is safe across the board.
I would advise against the use of CBD if pregnant or lactating at this time.
Incidentally, this mirrors my hypothesis that chemicals (xenoestrogens) in the environment are aiding and abetting the transgender “crisis” by altering neural pathways in the developing brain that deal with sexual identity.
To Your Excellent Health,
Robert Jay Rowen, MD
Studies have found that CBD, or cannabidiol, is effective for a range of health issues, but its use during pregnancy is not well-researched
“Scientific evidence has proven that CBD crosses the placenta, can reach the brain of rodents and human embryos and is also present in breast milk; therefore, it’s a public health priority to understand the impact of CBD on the developing nervous system as we don’t yet know the consequences of CBD exposure to the brain during development,” said Alba Caceres Rodriguez, a PhD student at INSERM Aix-Marseille University, a French public research organization that focuses on human health. “An important part of the research we are conducting in mice is longitudinal follow-up of the behavioral consequences of gestational exposure to CBD, and we are also investigating what is happening to the neurons in the brain that may be the basis of such changes in behavioral traits.”
The researchers administered a low dose of CBD (3 mg/kg) to pregnant mice by an injection under the skin from days five to 18 of the gestational period, more than two-thirds of pregnancy. Injecting the CBD, rather than administering it orally, ensured that each mouse received the same concentration. Another group of pregnant mice did not receive CBD and acted as controls.
Pups born to both groups of mice were tested once they reached adulthood. The researchers placed the mice in a new environment, and their social interactions were monitored with Live Mouse Tracker, software that uses a depth-sensing camera and machine learning to analyze the behavior of groups of mice in real-time. The results suggested that CBD altered specific mice behaviors and was sex-dependent.
“We found a number of behavioral changes among the mice exposed to CBD,” Caceres Rodriguez said. “CBD-exposed females tended to move around their new environment more compared to females that didn’t receive CBD during gestation. Furthermore, compared to control mice, both male and female mice treated with CBD established more physical contacts with each other.”
Examining the mice’s brains, the researchers found changes in two parts of the insular cortex (IC), the brain’s ‘integration hub’: the anterior IC (aIC), responsible for processing emotional and social signals, and the posterior IC (pIC), which processes pain perceptions and the body’s physical and emotional state.
“Our results reveal that prenatal exposure to CBD profoundly changes the functionality of neurons in the insular cortex,” Iezzi said. “We saw differences according to sex and also according to IC sub-regions. In particular, pyramidal neurons in the pIC lose their cellular identity following prenatal exposure to CBD and no longer behave like typical pIC neurons. This could have negative consequences on specific functions of the pIC. These neurons specialize in integrating sensory information from the environment and the internal state of the body in order to generate an appropriate behavioral response. Therefore, a loss of pIC differentiation following prenatal exposure to CBD can have a considerable impact on the ability to understand and react properly to the environment.”
The study’s findings advance our understanding of the effect of CBD use on the developing fetus and challenge the belief that it’s safe for pregnant women, the researchers say.
“These findings have significant implications for understanding the effects of CBD on fetal life, changing the general idea that CBD is a universally safe compound, and revealing the need for additional studies on the effect of prenatal CBD exposure,” said Iezzi. “Furthermore, several studies have shown that IC disfunction increases the risk of developing psychiatric disorders, including anxiety, addiction, depression and schizophrenia.”
Very interesting but how many people Inject CBD . Unless I missed something in the study the CBD was injected which is totally different than being ingested ?